Beilstein J. Org. Chem.2022,18, 95–101, doi:10.3762/bjoc.18.10
chemoenzymatic method was found to be superior over the chemical method in respect of the number of synthetic steps and overall yield of the final product.
Keywords: bicyclicAZTanalogues; bridged homoarabinofuranosylpyrimidine nucleosides; chemical pathway; Lipozyme® TL IM; regioselective enzymatic
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Graphical Abstract
Figure 1:
Structure of AZT and representative related bicyclic nucleosides.